A Spot-On product for the treatment and prevention of tick, flea and mite infestations in dogs and cats. In cats, Bravecto® Spot-On provides immediate and persistent flea and tick activity for 3 months. In dogs, Bravecto® Spot-On provides immediate and persistent tick activity for 4 months and flea activity for 6 months. Bravecto® Spot-On is well tolerated in MDR1 dogs. For the treatment and prevention of tick, flea and mite infestations in dogs and cats. Bravecto® Spot-On can be used as part of a treatment strategy for Flea Allergy Dermatitis (FAD). For the treatment of demodicosis caused by sarcoptic mange mites in dogs. For the treatment of Otodectes spp. mite infestations in dogs and cats. In dogs, Bravecto® Spot-On provides immediate and persistent tick activity for 4 months and flea activity for 6 months. Bravecto® Spot-On is well tolerated in MDR1 dogs.